Estimating excess mortality in people with cancer and multimorbidity in the COVID-19 emergency [Preprint]

Estimating excess mortality in people with cancer and multimorbidity in the COVID-19 emergency [Preprint]
ResearchGate accessed 29 April 2020 DOI: 10.13140/RG.2.2.34254.82242

• "The model estimated 6,270 excess deaths at 1 year in England."
• "In England, the proportion of patients with incident cancer with≥1 comorbidity was 65.2%. The number of comorbidities was strongly associated with can-cer mortality risk. "

Read a commentary on this research  here:

Deaths in people with cancer could rise by at least 20%
Imperial College Health Data Research Hub for Cancer 29 April 2020

Impact of comorbid conditions on outcomes of hip and knee replacement surgery: a systematic review and meta-analysis.

Impact of comorbid conditions on outcomes of hip and knee replacement surgery: a systematic review and meta-analysis.
BMJ Open. 2018 Jul 11;8(7):e021784. doi: 10.1136/bmjopen-2018-021784

• A meta-analysis (70 studies) of the association between different comorbid conditions on safety (short-term outcomes) and effectiveness (long-term outcomes) in patients undergoing hip and knee replacement surgery.  
• Twelve studies reported on the likelihood of revision surgery in patients with comorbid conditions. Overall, revision surgery tended to be more likely in patients with comorbid conditions (6 out of 11) but the evidence remains weak. The pooled OR ranged from 1.11 (95% CI 1.02 to 1.21) for patients with high blood pressure to 1.96 (95% CI 1.16 to 3.30) for patients with liver disease. No studies reported the risk of revision surgery in patients with poor circulation or stroke.

Abstract